Le ministère des Armées augmente le budget alloué à la biodiversité

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  25 décembre 2024 | International, Terrestre, C4ISR

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  12 novembre 2020 | International, Naval

  BAE Systems Secures $94M Contract to Deliver Advanced Tech to Navy

  Posted on November 10, 2020 by Seapower Staff MCLEAN, Va. — BAE Systems has been awarded a five-year, $94 million single-award indefinite delivery indefinite quantity contract to deliver advanced technology capability to the U.S. Navy. Building on 40 years of support to the U.S. Navy, this award from the Naval Air Warfare Center Aircraft Division's (NAWCAD) Webster Outlying Field (WOLF) enables the company to provide engineering, test, and evaluation support for sensors as well as communication, control, and weapons systems for various manned and unmanned airborne platforms. “We are bringing new advanced technologies such as artificial intelligence and autonomy to the Airborne Systems Integration Division,” said Mark Keeler, vice president and general manager of BAE Systems' Integrated Defense Solutions business. “Our state-of-the-art digital engineering capabilities, and extensive experience in integrating airborne systems are further strengthening the warfighter's ability to meet mission requirements and ensuring combat readiness in the field.” The award recognizes BAE Systems' investments in the development of model-based systems engineering capabilities. The company's ADAMS architecture provides a digital environment for systems engineering across multidisciplinary, multi-organization teams and stakeholders. On this contract, the company will use its innovative tools and methods such as digital engineering to create the digital thread that provides full design traceability to requirements, improved collaboration, and a digital repository for the Airborne Systems Integration Division. https://seapowermagazine.org/bae-systems-secures-94m-contract-to-deliver-advanced-tech-to-navy

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  30 novembre 2018 | International,

  Reinventing Drug Discovery and Development for Military Needs

  Flying at 50,000 feet, diving deep in the ocean, or hiking for miles with gear through extreme climates, military service members face conditions that place unique burdens on their individual physiology. The potential exists to develop pharmacological interventions to help service members complete their toughest missions more safely and efficiently, and then recover more quickly and without adverse effects, but those interventions must work on complex physiological systems in the human body. They will not be realized under the prevailing system of drug discovery and development with its focus on engaging single molecular targets. DARPA created the Panacea program to pursue the means of rapidly discovering, designing, and validating new, multi-target drugs that work with the body's complexity to better support the physiological resilience and recovery of military service members. The premise of Panacea is that the physiological systems of the human body work in complex and highly integrated ways. Drugs exert effects on our bodies by physically interacting with and changing the functional state of biomolecules that govern the functions of cells and tissues. Most drugs target proteins, which are the principle cellular workhorses. Ideally, drugs would target multiple proteins simultaneously to exert precise, network-level effects. One major problem facing the drug development community is that the functional proteome — the complete collection of proteins and their roles in signaling networks — is largely dark to science. Despite being able to identify many of the proteins within a cell, researchers do not have a firm grasp on everything those proteins do and how they interact to affect physiology. Due to this sparsity of structural and functional knowledge, the state of the art in drug development — what Panacea seeks to transform — is to engage only a very small fraction of known protein targets to achieve an effect. In fact, today's approach to drug design singles out individual proteins in certain cells. That hyper-specificity is an attempt to minimize the risk of side effects and speed time to market, but it also yields a thin stream of drugs, many of which have similar mechanisms and relatively muted effectiveness compared to what might be achieved using a multi-target, systems-based approach. “The current roster of drugs approved by the U.S. Food and Drug Administration only targets about 549 proteins, yet the body can produce more than six million different protein variants,” said Tristan McClure-Begley, the Panacea program manager. “The opportunity space for pharmacological intervention is vast and effectively untapped, but to access it we need new technology for understanding and targeting the human functional proteome.” Panacea will address the lack of functional knowledge about the proteome. DARPA's call to the research community is to consider complex physiological conditions relevant to military service members — for instance, metabolic stress during extreme endurance missions or pain and inflammation after injury; investigate the molecular mechanisms underlying those conditions; identify multiple, key molecular targets involved; and develop novel medicinal chemistry approaches to synthesize interventions that modulate those targets. DARPA believes that multi-target drugs will deliver safer and more efficacious solutions to military requirements for readiness and recovery over state-of-the-art interventions. “Many of the most successful drugs produced in the past were found rather than made, and we knew what they did long before we knew how they did it,” McClure-Begley said. “To deliver improved interventions, we need to get to a place where we can investigate all of the potential proteins at play for a given condition and then prioritize sets of protein targets and signaling networks to effectively modulate physiological systems, regardless of what prior knowledge exists about those targets.” The Panacea program aims to generate initial proof of concept for this new direction in drug discovery and development. Research will primarily involve animal models, human cell derived organoids, and high-throughput cell culture models. However, to support eventual transition to humans, DARPA will work with federal agencies to develop a regulatory pathway for future medical use. By the end of the five-year program, DARPA will require teams to submit novel drug candidates to the U.S. Food and Drug Administration for review as an Investigational New Drug or for Compassionate Use. DARPA will hold a Proposers Day on December 14, 2018, in Arlington, Virginia, to provide more information about Panacea and answer questions from potential proposers. For details of the event, including registration requirements, visit https://go.usa.gov/xP6hD. A forthcoming Broad Agency Announcement will fully describe the program structure and objectives. https://www.darpa.mil/news-events/2018-11-28