Pentagon to identify next Replicator capability set this summer

On the same subject

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  November 30, 2018 | International,

  Reinventing Drug Discovery and Development for Military Needs

  Flying at 50,000 feet, diving deep in the ocean, or hiking for miles with gear through extreme climates, military service members face conditions that place unique burdens on their individual physiology. The potential exists to develop pharmacological interventions to help service members complete their toughest missions more safely and efficiently, and then recover more quickly and without adverse effects, but those interventions must work on complex physiological systems in the human body. They will not be realized under the prevailing system of drug discovery and development with its focus on engaging single molecular targets. DARPA created the Panacea program to pursue the means of rapidly discovering, designing, and validating new, multi-target drugs that work with the body's complexity to better support the physiological resilience and recovery of military service members. The premise of Panacea is that the physiological systems of the human body work in complex and highly integrated ways. Drugs exert effects on our bodies by physically interacting with and changing the functional state of biomolecules that govern the functions of cells and tissues. Most drugs target proteins, which are the principle cellular workhorses. Ideally, drugs would target multiple proteins simultaneously to exert precise, network-level effects. One major problem facing the drug development community is that the functional proteome — the complete collection of proteins and their roles in signaling networks — is largely dark to science. Despite being able to identify many of the proteins within a cell, researchers do not have a firm grasp on everything those proteins do and how they interact to affect physiology. Due to this sparsity of structural and functional knowledge, the state of the art in drug development — what Panacea seeks to transform — is to engage only a very small fraction of known protein targets to achieve an effect. In fact, today's approach to drug design singles out individual proteins in certain cells. That hyper-specificity is an attempt to minimize the risk of side effects and speed time to market, but it also yields a thin stream of drugs, many of which have similar mechanisms and relatively muted effectiveness compared to what might be achieved using a multi-target, systems-based approach. “The current roster of drugs approved by the U.S. Food and Drug Administration only targets about 549 proteins, yet the body can produce more than six million different protein variants,” said Tristan McClure-Begley, the Panacea program manager. “The opportunity space for pharmacological intervention is vast and effectively untapped, but to access it we need new technology for understanding and targeting the human functional proteome.” Panacea will address the lack of functional knowledge about the proteome. DARPA's call to the research community is to consider complex physiological conditions relevant to military service members — for instance, metabolic stress during extreme endurance missions or pain and inflammation after injury; investigate the molecular mechanisms underlying those conditions; identify multiple, key molecular targets involved; and develop novel medicinal chemistry approaches to synthesize interventions that modulate those targets. DARPA believes that multi-target drugs will deliver safer and more efficacious solutions to military requirements for readiness and recovery over state-of-the-art interventions. “Many of the most successful drugs produced in the past were found rather than made, and we knew what they did long before we knew how they did it,” McClure-Begley said. “To deliver improved interventions, we need to get to a place where we can investigate all of the potential proteins at play for a given condition and then prioritize sets of protein targets and signaling networks to effectively modulate physiological systems, regardless of what prior knowledge exists about those targets.” The Panacea program aims to generate initial proof of concept for this new direction in drug discovery and development. Research will primarily involve animal models, human cell derived organoids, and high-throughput cell culture models. However, to support eventual transition to humans, DARPA will work with federal agencies to develop a regulatory pathway for future medical use. By the end of the five-year program, DARPA will require teams to submit novel drug candidates to the U.S. Food and Drug Administration for review as an Investigational New Drug or for Compassionate Use. DARPA will hold a Proposers Day on December 14, 2018, in Arlington, Virginia, to provide more information about Panacea and answer questions from potential proposers. For details of the event, including registration requirements, visit https://go.usa.gov/xP6hD. A forthcoming Broad Agency Announcement will fully describe the program structure and objectives. https://www.darpa.mil/news-events/2018-11-28

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  August 29, 2024 | International, Aerospace

  Intuitive Machines gets $116.9 mln NASA contract for delivery to Moon's south pole

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  November 20, 2018 | International, Aerospace, Naval, Land, C4ISR, Security

  Contract Awards by US Department of Defense - November 19, 2018

  ARMY Arora Group Inc.,* Gaithersburg, Maryland, was awarded an $85,457,545 firm-fixed-price contract to provide personal and non-personal services. Bids were solicited via the internet with 25 received. Work locations and funding will be determined with each order, with an estimated completion date of Sept. 30, 2023. U.S. Army Health Contracting Activity, San Antonio, Texas, is the contracting activity (W81K00-19-D-0002). Birdon America Inc.,* Denver, Colorado, was awarded a $44,452,448 modification (P00062) to contract W56HZV-14-C-0015 for bridge erection boats and crew protection kits. Work will be performed in Denver, Colorado, with an estimated completion date of March 31, 2020. Fiscal 2019 other procurement, Army funds in the amount of $44,452,448 were obligated at the time of the award. U.S. Army Contracting Command, Warren, Michigan, is the contracting activity. URS Federal Services Inc., Germantown, Maryland, was awarded a $20,000,000 modification (0002 36) to contract W52P1J-12-G-0028 for logistic support services, maintenance, supply and transportation. Work will be performed in Mannheim and Dulmen, Germany, with an estimated completion date of Nov. 20, 2021. Fiscal 2019 operations and maintenance Army funds in the amount of $20,000,000 were obligated at the time of the award. U.S. Army Contracting Command, Rock Island Arsenal, Illinois, is the contracting activity. CSRA LLC, Huntsville, Alabama, was awarded an $8,790,283 modification (000033) to Foreign Military Sales (Uganda, Iraq, Croatia, Greece, Tunisia, Indonesia, Kenya, Saudi Arabia and Afghanistan) contract W31P4Q-05-A-0028 for non-standard rotary wing aircraft project office systems engineering and technical assistance support services. Work will be performed in Huntsville, Alabama, with an estimated completion date of Nov. 19, 2019. Fiscal 2018 other procurement, Army; and foreign military sales funds in the amount of $8,790,283 were obligated at the time of the award. U.S. Army Contracting Command, Redstone Arsenal, Alabama, is the contracting activity. NAVY Northrop Grumman Systems Corp., Herndon, Virginia (N00189-19-D-Z006); Capstone Corp., Alexandria, Virginia (N00189-19-D-Z007); Science Applications Information Corp., Reston, Virginia (N00189-19-D-Z008); General Dynamic Information Technology, Fairfax, Virginia (N00189-19-D-Z009); Booz Allen Hamilton Inc., McLean, Virginia (N00189-19-D-Z010); and CALIBRE Systems Inc., Alexandria, Virginia (N00189-19-D-Z011), are awarded an estimated $577,471,075 in multiple award cost-plus-fixed-fee, indefinite-delivery/indefinite-quantity contracts that will include terms and conditions for the placement of both cost-plus-fixed-fee and firm-fixed-price task orders to provide Joint Force development and training support services to enhance and improve the joint fighter's ability to adapt and overcome an ever-evolving threat environment in support of the Joint Chiefs of Staff. The contracts will run concurrently and include a 60-month base ordering period with an option for an additional six-month ordering period. If the option period is exercised, the total estimated value of the contracts combined will be $636,917,163. Work will be performed at government facilities in Suffolk, Virginia (90 percent); and at various contractor locations throughout the U.S. (10 percent). The percentage of work at each of the contractor facilities cannot be determined at this time. The base ordering period of the contract is anticipated to begin May 2019 and is expected to be completed by April 2024; if all options are exercised, the ordering period will be completed by October 2024. Fiscal 2019 operations and maintenance (Defense Acquisition) funds in the amount of $60,000 will be obligated ($10,000 on each of the six contracts to fund the contracts' minimum amounts); and funds will expire at the end of the current fiscal year. This contract was competitively procured for the award of multiple contracts pursuant to the authority set forth in Federal Acquisition Regulation 16.504. The requirement was solicited through the Federal Business Opportunities website, with eight offers received. Naval Supply Systems Command Fleet Logistics Center Norfolk, Contracting Department Philadelphia, Pennsylvania, is the contracting activity. Lockheed Martin Corp., Lockheed Martin Aeronautics Co., Fort Worth, Texas, is awarded a $41,509,096 firm-fixed-price delivery order (N00019-18-F-2494) against a previously issued basic ordering agreement (N00019-14-G-0020). This modification procures Xilinx and Intel-Altera Diminishing Manufacturing Sources parts that have reached end-of-life in order to support future aircraft deliveries for the Air Force, Marine Corps, and Navy as well as Foreign Military Sales (FMS) customers. Work will be performed in Fort Worth, Texas, and is expected to be completed in February 2019. Fiscal 2017 aircraft procurement (Air Force); 2018 aircraft procurement (Air Force, Marine Corps and Navy); 2019 operations and maintenance (Air Force, Marine Corps, and Navy); and FMS funding in the amount of $41,509,096 will be obligated at time of award, $32,836,293 of which will expire at the end of the current fiscal year. This delivery order combines purchases for the Air Force ($22,936,546; 55 percent); Marine Corps ($13,505,208; 33 percent); Navy ($4,766,733; 11 percent); and FMS ($300,609; 1 percent). The Naval Air Systems Command, Patuxent River, Maryland, is the contracting activity. CRP Contracting,* Columbus, Ohio, is awarded a $31,116,904 firm-fixed-price contract for airfield lighting repairs at Naval Air Station Kingsville. The work to be performed provides for repairs to the airfield electrical infrastructure. The work also includes removal and installation of a new standing seam roof and removal and replacement of windows and incidental related work. Work will be performed in Kingsville, Texas, and is expected to be completed by November 2020. Fiscal 2019 operations and maintenance (Navy) contract funds in the amount of $31,116,904 are obligated on this award and will expire at the end of the current fiscal year. This contract was competitively procured via the Navy Electronic Commerce Online website, with two proposals received. The Naval Facilities Engineering Command, Southeast, Jacksonville, Florida, is the contracting activity (N69450-19-C-0503). Triton Marine Construction Corp., Bremerton, Washington, was awarded a $17,914,200 firm-fixed-price contract for the repair of trestle box beams at Naval Weapons Station Earle. The work to be performed provides for concrete spall repairs on the underside of Trestle 1A to the pile caps, beams, and deck; carbon fiber reinforced polymer strengthening of existing reinforced concrete box beams using the wet layup process; and installation of five new pile bents ten new piles will be driven on Trestle 1A to strengthen the existing box beams. Work will be performed in Colts Neck, New Jersey, and is expected to be completed by March 2024. Fiscal 2019 operations and maintenance (Navy) contract funds in the amount of $17,914,200 are obligated on this award and will not expire at the end of the current fiscal year. This contract was competitively procured via the Navy Electronic Commerce Online website, with six proposals received. The Naval Facilities Engineering Command, Mid-Atlantic, Norfolk, Virginia, is the contracting activity (N40085-19-C-9032). (Awarded Nov. 16, 2018). Telephonics Corp., Farmingdale, New York, is awarded a $15,130,351 firm-fixed-price indefinite-delivery/indefinite-quantity contract. This contract provides for the procurement of a maximum quantity of 50 Identification Friend or Foe Interrogator (IFFI) AN/UPX-43(V) 1 and 50 IFFI mounting trays, repair of repairables and required technical data in support of P-8A Poseidon Production Lots 9, 10, and 11 for the Navy, partner countries and foreign military sales (FMS) customers. Work will be performed in Farmingdale, New York, and is expected to be completed in November 2021. Fiscal 2018 aircraft procurement (Navy); and FMS funds in the amount of $3,588,904 will be obligated at time of award; none of which will expire at the end of the current fiscal year. The first order combines purchases for the Navy ($2,687,946; 75 percent); and the government of the United Kingdom ($900,958; 25 percent). This contract was not competitively procured pursuant to 10 U.S. Code 2304(c)(1). The Naval Air Warfare Center Aircraft Division, Lakehurst, New Jersey, is the contracting activity (N68335-19-D-0002). CFM International Inc., West Chester, Ohio, is awarded $13,033,283 for modification P00002 to a previously awarded firm-fixed-price contract (N0001918C1071) to exercise an option for the procurement of one Poseidon CFM56-7B27AE engine for the government of Norway in support of the P-8 Poseidon aircraft under the Foreign Military Sales program. Work will be performed in Villaroche, France (53 percent); Evendale, Ohio (43 percent); Singapore (3 percent); and Bromont, Canada (1 percent), and is expected to be completed in September 2019. Foreign Military Sales funds in the amount of $13,033,283 will be obligated at time of award, none of which will expire at the end of the current fiscal year. The Naval Air Systems Command, Patuxent River, Maryland, is the contracting activity. Colonna's Shipyard Inc.,* Norfolk, Virginia, is awarded an $11,884,493 firm-fixed-price contract for a 90-calendar day shipyard availability for the post shakedown availability and dry docking of USNS City of Bismarck (T-EPF 9). Work will include clean and gas-free tanks, voids, cofferdams and spaces, heater exchangers; modify fore peak structure, perform annual stern ramp maintenance, install heat tracing and thermal insulation on piping, perform annual maintenance of ride control system, bilge cleaning, reduction gear maintenance, self-contained breathing apparatus annual certification, high expansion foam system certification, heating, ventilation, and air conditioning system annual maintenance, annual sewage plant maintenance, docking and undocking, evacuation system annual certification, waterjet hydraulics maintenance, and installation of the adaptive force package. The contract includes options which, if exercised, would bring the total contract value of this contract to $13,593,593. Work will be performed in Norfolk, Virginia, and is expected to begin Jan. 7, 2019, with completion by April 6, 2019. Fiscal 2019 operations and maintenance funds in the amount of $13,593,593 are obligated at the time of award. Contract funds will not expire at the end of the current fiscal year. This contract was competitively procured as a small business set-aside, with more than two companies solicited via the Federal Business Opportunities website, with two offers received, with two found to be in the competitive range. The Navy's Military Sealift Command, Norfolk, Virginia, is the contracting activity (N3220519C6702). 3 Phoenix Inc.,* Chantilly, Virginia, is awarded a $10,271,000 cost-plus-fixed-fee, cost only modification to previously awarded contract N00024-13-C-6264 to exercise an option for engineering and technical services and other direct costs in support thereof for the Small Business Innovative Research (SBIR) Phase III contract, topic number N04-138-Real-time Data Fusion and Visualization Interface for Environmental Research Data. Work will be performed in Chantilly, Virginia (40 percent); Wake Forest, North Carolina (40 percent); and Hanover, Maryland (20 percent), and is expected to be completed by October 2019. Fiscal 2017 shipbuilding and conversion (Navy); fiscal 2018 and 2019 other procurement (Navy); and fiscal 2018 research, development, test and evaluation (Navy) funding in the amount of $6,753,273 will be obligated at the time of award and funding in the amount of $724,610 will expire at the end of the current fiscal year. The Naval Sea Systems Command, Washington, District of Columbia, is the contracting activity. Kellogg Brown and Root Services Inc., Houston, Texas, is awarded $9,847,635 for task order A00012 under previously awarded firm-fixed-price, indefinite-delivery/indefinite-quantity contract N62470-17-D-4012 for modification of the first option period for base operations support services at Camp Lemonnier, Djibouti, and other areas within Africa. The work to be performed provides for all management and administration, public safety, galley, ordnance, air operations, fire and emergency services, bachelor quarters, housing, pest control, integrated solid waste, base support vehicles and equipment, custodial, electrical, water, wastewater, port operations, supply, morale-welfare-recreation, facilities investment, and environmental services to provide base operations support services. After award of this option, the total cumulative contract value will be $132,110,862. Work will be performed at various installations in territory of Djibouti, Africa; and other areas within Africa, and is expected to be completed November 2019. No funds will be obligated at time of award. The Naval Facilities Engineering Command, Europe Africa Southwest Asia, Naples, Italy, is the contracting activity. VT Halter Marine Inc., Pascagoula, Mississippi, was awarded a not-to-exceed $9,000,0000 undefinitized contract action for functional design engineering, procurement of long-lead time material, and limited advanced production to support the Oceanographic Survey Ship (T-AGS 67). Work will be performed in Pascagoula, Mississippi (85 percent); Pittsburgh, Pennsylvania (13 percent); and New Orleans, Louisiana (2 percent), and is expected to be completed by May 2019. Fiscal 2018 shipbuilding and conversion (Navy) funding in the amount of $6,750,000 will be obligated at time of award and will not expire at the end of the current fiscal year. This contract was not competitively procured, in accordance with 10 U.S. Code 2304(c)(1) - only one responsible source and no other supplies or services will satisfy agency requirements. The Naval Sea Systems Command, Washington, District of Columbia, is the contracting activity (N00024-18-C-2208). (Awarded Nov. 16, 2018) Lockheed Martin Corp. Mission Systems and Training, Baltimore, Maryland, is awarded $7,105,135 for a firm-fixed-price contract for the manufacture of spare and repair parts used in the MK-41 Vertical Launching System. This is a one-year contract with no option periods. Work will be performed in Ventura, California (85 percent); and Baltimore, Maryland (15 percent), and will be completed by November 2019. Fiscal 2018 and 2019 working capital funds (Navy) in the amount of $7,105,135 will be issued as a delivery order that will be awarded concurrently with the contract. Funds will not expire at the end of the current fiscal year. One company was solicited for this non-competitive requirement and one offer was received in response to the original solicitation in accordance with 10 U.S. Code 2304(c)(1). Naval Supply Systems Command Weapon Systems Support, Mechanicsburg, Pennsylvania, is the contracting activity (N00104-19-D-ZD21). AIR FORCE Northrop Grumman Aerospace Systems, San Diego, has been awarded a $489,924,430 definitization and increase in scope fixed-price-incentive-fee and cost-plus-incentive-fee contract (FA8620-18-C-1000 PZ0004) for the Japan Global Hawk program. The contract provides for: three RQ-4 Global Hawk Block 30i air vehicles each containing an enhanced integrated sensor suite payload, two ground control elements, spares and support equipment, system engineering and program management tasks required to execute, manage, control, and report on all program activities, and a site survey. Work will be performed in San Diego and is expected to be completed by Sept. 1, 2022. This contract involves foreign military sales (FMS) to Japan and is the result of a sole-source acquisition. This action will increase funding by $294,542,454 for a total of $425,012,030 in FMS funding. FMS funding in the amount of $64,912,400 will be awarded as priced options to be exercised as soon as Japan releases the remaining funds. Air Force Life Cycle Management Center, Wright-Patterson Air Force Base, Ohio, is the contracting activity. Thales Air Traffic Management Inc., Clarksburg, Maryland, has been awarded a $30,634,338 firm-fixed-price contract option for Deployable Instrument Landing System (D-ILS) production units and spare parts. This contract option provides 9 D-ILS to be deployed worldwide. Work will be performed in Clarksburg, Maryland, and is expected to be completed September 2020. Fiscal 2017 and 2018 procurement funds in the amount of $30,634,338 are being obligated at the time of award. The total cumulative face value of the contract is $126,104,149 and has not changed with this award. Aerospace Management Systems Contracting Office, Hanscom Air Force Base, Massachusetts, is the contracting activity (FA8730-18-C-0034). Engility Corp., Andover, Massachusetts, has been awarded a $30,304,806 cost-plus-incentive-fee contract for systems engineering and integration follow-on services. This contract provides support to ensure the Air Force Space Overhead Persistent Infrared and Space Based Environmental Monitoring program requirements are met in a timely manner. Work will be performed in El Segundo, California, and is expected to be completed by Feb. 28, 2021. This award is the result of a competitive acquisition and one offer was received. Fiscal 2019 research, development, test and evaluation funds in the amount of $15,48,920; space procurement funds in the amount of $783,582; and operations and maintenance funds in the amount of 1,934,075 will be obligated at the time of award. Space and Missile Systems Center, Los Angeles Air Force Base, California, is the contracting activity (FA8810-19-F-0001). MISSILE DEFENSE AGENCY Lockheed Martin Corp. - Rotary and Mission Systems, Colorado Springs, Colorado, is being competitively awarded an indefinite-delivery/indefinite quantity contract with a maximum amount of $240,000,000. Under this new contract, the contractor will support the development, deployment and sustainment of the Objective Simulation Framework Modeling & Simulation framework that leverages existing or mature capabilities with a modular, scalable, reconfigurable, and composeable architecture. A task order in the amount of $49,703,444 is being issued immediately after the award of this contract. The work will be performed in Huntsville, Alabama. The ordering period is from Nov. 19, 2018, through Nov. 18, 2023. This contract was competitively procured via publication on the Federal Business Opportunities website with three proposals received. Fiscal 2018 research and development funds in the amount of $1,700,000 are being obligated on the award of the first task order and will expire at the end of the current fiscal year. The Missile Defense Agency, Redstone Arsenal, Alabama, is the contracting activity (HQ0147-19-D-0002). DEFENSE LOGISTICS AGENCY Coastal Pacific Food Distributors, Stockton, California, has been awarded a maximum $52,000,000 fixed-price with economic-price-adjustment, indefinite-delivery/indefinite-quantity contract for full food-line distribution. This is a 142-day bridge contract, which could possibly end early when the guaranteed minimum is met. Locations of performance are California, Japan, Singapore, Philippines and Diego Garcia, with an April 30, 2019, performance completion date. Using military services are Army, Navy, Air Force and Marine Corps. Type of appropriation is fiscal 2019 defense working capital funds. The contracting agency is the Defense Logistics Agency Troop Support, Philadelphia, Pennsylvania (SPE300-19-D-4046). Burlington Apparel Fabrics, Greensboro, North Carolina, has been awarded a maximum $47,951,352 firm-fixed-price, indefinite-delivery contract for blue poly/wool cloth. This was a competitive acquisition with one response received. This is a one-year contract with four one-year option periods. The maximum dollar amount is for the life of the contract. Location of performance is North Carolina, with a Nov. 18, 2023, performance completion date. Using military service is Army. Type of appropriation is fiscal 2019 through 2023 defense working capital funds. The contracting activity is the Defense Logistics Agency Troop Support, Philadelphia, Pennsylvania (SPE1C1-19-D-1113). *Small business https://dod.defense.gov/News/Contracts/Contract-View/Article/1694434/source/GovDelivery/